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Wegovy Dosing Guide: Understanding Your Dosage Schedule

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, 5 min read

Wegovy Dosing Guide: Understanding Your Dosage Schedule

Wegovy (semaglutide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) and for chronic weight management in adults with obesity or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. In the UK, Wegovy can be accessed by individuals enrolled in specialised NHS weight management programs who satisfy the NICE guidelines for eligibility, or it can be obtained privately through a certified healthcare provider. To get the most out of Wegovy, it's important to understand the proper dosing schedule and how to adjust it based on your individual needs.

Who Can Benefit from Wegovy?

Wegovy is approved for adults with:

  • A Body Mass Index (BMI) of 30 kg/m² or higher (obesity)
  • A BMI of 27 kg/m² to less than 30 kg/m² (overweight) with weight-related health issues

Additionally, Wegovy is eligible for weight management in adolescents aged 12 years and above with obesity and a body weight greater than 60kg, contingent upon a significant weight loss after 12 weeks of treatment at the maximum dosage.

Starting Dose and Titration

Wegovy's administration begins with a low dose, which is gradually increased over the first 16 weeks to mitigate side effects. The starting dose is 0.25 mg once weekly, with gradual increments every 4 weeks, reaching the maintenance dose of 2.4 mg once weekly. This stepped approach ensures patient tolerance and effectiveness of the treatment.

Adolescents follow the same dosage escalation, with a focus on reaching either the 2.4 mg maintenance dose or the maximum tolerated dose, underlining the individualised nature of treatment based on patient response.

Month 10.25 mg weekly
Month 20.5 mg weekly
Month 31 mg weekly
Month 41.7 mg weekly
Month 5 and beyond2.4 mg weekly (maintenance dose)

This gradual titration schedule is designed to help your body adapt to the medication and minimise side effects. Your healthcare provider may adjust the titration based on your individual response and tolerance. 

Wegovy pen setup and calendar with marked dates for increasing Wegovy dosage

Read more: Switching from Wegovy to Mounjaro: How To Guide for Patients

Factors Affecting Dosage

Several factors can influence the appropriate Wegovy dosage for you, including:

  • Body weight and BMI: Wegovy dosages are not strictly based on weight, but your healthcare provider may adjust the dose based on your BMI and response to the medication.
  • Existing medical conditions: Certain health conditions, such as diabetes or heart disease, may require a lower starting dose or slower titration to avoid potential interactions. 
  • Tolerance and side effects: If you experience significant side effects at a particular dose, your healthcare provider may keep you at that dose for longer or even reduce the dose to help your body adjust. 

Missed Doses and Adjustments

It's important to take Wegovy at the same time each week to maintain consistent blood levels of the medication. If you miss a dose and the next scheduled dose is more than 48 hours away, take the missed dose as soon as possible. If the next dose is less than 48 hours away, skip the missed dose and take the next one as scheduled.

If you miss multiple doses, contact your healthcare provider for guidance on how to restart your treatment. They may recommend starting at a lower dose and gradually titrating back up to your previous maintenance dose.

Frequently Ask Questions

Q: How long does it take for wegovy to work?
Wegovy may start showing some initial weight loss effects within the first 4 weeks at the starting 0.25 mg dose, but the full weight loss benefits are typically seen after reaching the 2.4 mg maintenance dose, which takes about 17 weeks to reach. Consistent adherence to the dosing schedule is important for maximising the weight loss results with Wegovy.

Q: Can I inject half a dose of Wegovy?
No. Wegovy pens deliver precise doses, and altering them can be unsafe. The gradual dose increase is designed to minimise side effects. Always follow your doctor's instructions. If you have concerns about your dosage, consult your clinician for guidance.


Achieving successful weight loss with Wegovy requires a personalised approach to dosing. By starting at a low dose and gradually increasing it over time, your healthcare provider can help you find the right balance between efficacy and tolerability. Remember to follow your healthcare provider's instructions closely and communicate any concerns or side effects you experience. With the right Wegovy dosage, you can take an important step towards reaching your weight management goals.

If you're in search of a safe and tested clinical-led weight management program, look no further. Join the eMed Weight Management Programme today. Our program is designed to support your journey with personalised plans and expert guidance. Take the first step towards a healthier you. Click here to join eMed and start your journey today!


The information provided is for educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Seek the advice of a doctor with any questions you may have regarding a medical condition. Never delay seeking or disregard professional medical advice because of something you have read here.

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